Title of article
Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr
Author/Authors
Ahmed El Akkaoui، نويسنده , , A. and Koubachi، نويسنده , , J. and El Kazzouli، نويسنده , , S. and Berteina-Raboin، نويسنده , , S. and Mouaddib، نويسنده , , A. and Guillaumet، نويسنده , , G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
2472
To page
2475
Abstract
The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo[1,2-b]pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858878
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