Title of article
A new synthesis of pyrrolidines via imino-aldol reaction of (2-trimethylsilylmethyl)cyclopropyl ketones with imines
Author/Authors
Yadav، نويسنده , , Veejendra K. and Gupta، نويسنده , , Archana، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3212
To page
3215
Abstract
A new synthesis of 2,3,5-trisubstituted pyrrolidines from the imino-aldols formed from Lewis acid-mediated reactions of (2-trimethylsilylmethyl)cyclopropyl ketones with benzylimines is described. The ring closure of the imino-aldols formed from the benzylimines of 2-chloro-, 2-fluoro-, and 2-trifluoromethylbenzaldehydes proceeds with predominantly 2,5-anti selectivity to generate the corresponding pyrrolidines in moderate yields.
Keywords
Imino-aldol , Hg(II)-promoted aza-ring closure , (2-Trimethylsilylmethyl)cyclopropyl ketone , Enolate , 5-Trisubstituted pyrrolidine , 3 , 2
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859213
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