Title of article
Organo-catalyzed highly diastereo- and enantio-selective direct aldol reactions in water
Author/Authors
Zhao، نويسنده , , Jun-Feng and He، نويسنده , , Long and Jiang، نويسنده , , Jun and Tang، نويسنده , , Zhuo and Cun، نويسنده , , Lin-Feng and Gong، نويسنده , , Liu-Zhu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3372
To page
3375
Abstract
The asymmetric direct aldol reactions of a wide scope of aromatic aldehydes, with unmodified ketones in the presence of 1 mol % of organocatalyst prepared from (2R,3R)-diethyl 2-amino-3-hydroxysuccinate and trans-4-hydroxy-l-proline, were performed in water, affording aldol products in high yields with excellent diastereoselectivities of up to >99:1 and enantioselectivities of up to 98%.
Keywords
water , organocatalysis , Direct aldol , Diastereo- and enantio-selective
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859282
Link To Document