Title of article
A one-pot stereoselective synthesis of trans-1-aryl-2-aminotetralins from 2-arylethyl styrenes
Author/Authors
Hajra، نويسنده , , Saumen and Maji، نويسنده , , Biswajit and Sinha، نويسنده , , Debarshi and Bar، نويسنده , , Sukanta، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
4057
To page
4059
Abstract
An efficient stereoselective synthesis of trans-1-aryl-2-aminotetralins has been achieved via Cu(OTf)2 catalyzed one-pot aziridination and regioselective intramolecular arylation of in situ generated aziridines from 2-arylethyl styrenes and PhINSO2(4-NO2C6H4) [PhINNs]. Reaction of a mixture of E/Z-styrenes (⩽85:15) provided trans-N-protected-1-aryl-2-aminotetralins with high diastereoselectivity (dr > 95:5), which are important synthons for many artificial pharmaceuticals.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859590
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