Title of article
Rapid stereoselective access to the tetracyclic core of puupehenone and related sponge metabolites using metal-free radical cyclisations of cyclohexenyl-substituted 3-bromochroman-4-ones
Author/Authors
Pritchard، نويسنده , , Robin G. and Sheldrake، نويسنده , , Helen M. and Taylor، نويسنده , , Isobel Z. and Wallace، نويسنده , , Timothy W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
4156
To page
4159
Abstract
The tetracyclic nucleus of puupehenone, 15-oxopuupehenol and other sesquiterpene–phenol natural products can be assembled stereoselectively in three steps, the last of these being the 6-endo-trig cyclisation of an alpha-keto radical generated from a substituted 2-(2-cyclohexenyl)ethyl 3-bromo-4-chromanone under metal-free conditions.
Keywords
Sesquiterpene–phenol , Puupehenone , Radical cyclisation , 6-endo-Trig , Lauroyl peroxide , Merosesquiterpene , ?-bromoketone
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859644
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