Title of article
Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes
Author/Authors
Dirr، نويسنده , , Ronan and Anthaume، نويسنده , , Cyril and Désaubry، نويسنده , , Laurent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
4588
To page
4590
Abstract
An efficient approach to unsymmetrical halogenated resorcinol diethers has been developed. This synthesis consists of two subsequent nucleophilic aromatic substitutions (SNAr) of unsymmetrical difluoroarenes by alkoxides. The novelty of this approach is its control of regioselectivity during the first SNAr, which occurs at room temperature. Interestingly, the reactivity of competing fluorines was correlated to their chemical shift in 19F NMR.
Keywords
SNAr , Fluorine substitution , 19F NMR
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859861
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