Title of article
A practical synthesis of (E)-2-cyclopentadecen-1-one: an important precursor of macrocyclic muscone
Author/Authors
Hisanaga، نويسنده , , Yusuke and Asumi، نويسنده , , Yuya and Takahashi، نويسنده , , Masaki and Shimizu، نويسنده , , Yasuhiro and Mase، نويسنده , , Nobuyuki and Yoda، نويسنده , , Hidemi and Takabe، نويسنده , , Kunihiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
548
To page
551
Abstract
A practical synthesis of (E)-2-cyclopentadecen-1-one (E)-2 which is an important precursor of macrocyclic muscone (1) was investigated. Olefination of 2-mesyloxycyclopentadecanone (7c) with strong acid such as sulfuric acid or trifluoromethanesulfonic acid afforded the desired (E)-2 in high yield with extremely high stereoselectivity, which was treated with methylmagnesium cuprate to furnish the dl-muscone in good yield.
Keywords
Macrocycles , Muscone , elimination
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860078
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