Title of article
Microwave acceleration in DABAL-Me3-mediated amide formation
Author/Authors
Glynn، نويسنده , , Daniel and Bernier، نويسنده , , David I. Woodward، نويسنده , , Simon، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
2
From page
5687
To page
5688
Abstract
Facile direct coupling of esters and secondary amines to afford tertiary amides proceeds under microwave irradiation using the air-stable trimethylaluminium source DABAL-Me3 [(DABCO)(AlMe3)2]. Excellent yields (88–98%) are attained for cyclic secondary amines in reactions that are complete in 5–16 min. The process can be extended to the formation of Weinreb amides (upto 76% from commercial MeNHOMe·HCl) in a one-pot procedure using NaH to liberate the free methoxyamine.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860944
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