Title of article
Access to chiral tertiary amines via the iridium-catalyzed asymmetric hydrogenation of enamines
Author/Authors
Cheruku، نويسنده , , Pradeep and Church، نويسنده , , Tamara L. and Trifonova، نويسنده , , Anna and Wartmann، نويسنده , , Thomas and Andersson، نويسنده , , Pher G. Andersson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
7290
To page
7293
Abstract
The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee.
Keywords
Asymmetric catalysis , enamines , Hydrogenation , Chiral tertiary amines
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1862004
Link To Document