Title of article
Diphenylphosphinoylethylidene (DPE) acetals: an alternative protective strategy in glycochemistry
Author/Authors
Pellizzaro، نويسنده , , Leonardo and Tatibouët، نويسنده , , Arnaud and Fabris، نويسنده , , Fabrizio and Rollin، نويسنده , , Patrick and Lucchi، نويسنده , , Ottorino De Lucchi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
101
To page
103
Abstract
Diphenylphoshinoylethyne reacts with diols under basic conditions to produce cycloacetalic phosphine oxides. The reaction appears to be general and particularly effective with carbohydrate derivatives. The 2-(diphenylphoshinoyl)ethylidene (DPE) acetals produced are stable in acidic media while they can be cleaved under reductive and/or basic conditions: base-catalyzed transacetalization is a method of choice for their mild and effective deprotection.
Keywords
Cyclic acetals , protective groups , Ethynylphosphine oxide , carbohydrates
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862180
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