Title of article
Diastereocontrolled addition of organometallic reagents to S-chiral N-(tert-butanesulfinyl)-α-fluoroenimines
Author/Authors
Pierry، نويسنده , , Camille and Zoute، نويسنده , , Ludivine and Jubault، نويسنده , , Philippe and Pfund، نويسنده , , Emmanuel and Lequeux، نويسنده , , Thierry and Cahard، نويسنده , , Dominique and Couve-Bonnaire، نويسنده , , Samuel and Pannecoucke، نويسنده , , Xavier، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
264
To page
266
Abstract
Grignard and organolithium reagents efficiently react with (S)-N-(tert-butanesulfinyl)-α-fluoroenimines to provide chiral allylamines in excellent yields and with diastereomeric ratios of up to 96:4. Acidic removal of the sulfinyl group and simple functional group transformations allow to get enantiopure fluoroolefin dipeptide mimics.
Keywords
Peptides mimics , Fluorine compounds , Enimines , diastereoselective synthesis , Grignard
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862288
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