Title of article
Enantioselective synthesis of (R)- and (S)-N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs
Author/Authors
Fish، نويسنده , , Paul V. and Mackenny، نويسنده , , Malcolm and Bish، نويسنده , , Gerwyn and Buxton، نويسنده , , Timothy and Cave، نويسنده , , Russell and Drouard، نويسنده , , David and Hoople، نويسنده , , David and Jessiman، نويسنده , , Alan and Miller، نويسنده , , Duncan and Pasquinet، نويسنده , , Christelle and Patel، نويسنده , , Bhairavi and Reeves، نويسنده , , Keith and Ryckmans، نويسنده , , Thomas and ، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
389
To page
391
Abstract
The (R)- and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and stereoselectively to reboxetine analogs 3 and 4.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862367
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