Title of article
Stereoselective synthesis of methyl (Z)-α-methoxyacrylates via two-carbon homologation of aldehydes
Author/Authors
Baati، نويسنده , , Rachid and Mioskowski، نويسنده , , Charles and Kashinath، نويسنده , , Dhurke and Kodepelly، نويسنده , , Sanjeevarao and Lu، نويسنده , , Biao and Falck، نويسنده , , J.R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
402
To page
405
Abstract
Methyl (Z)-α-methoxyacrylates are generated in good yields by a mild, stereospecific two-carbon homologation of a wide variety of aldehydes utilizing commercial methyl 2,2-dichloro-2-methoxyacetate and CrCl2 under Barbier conditions at room temperature. A rational mechanism based upon a Reformatsky-type addition pathway or an in situ generated (E)-trioxo-chromium vinylidene carbenoid is proposed.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862375
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