Title of article
[18F]Fluoroamines via ring-opening of N-Cbz-2-methylaziridine with [18F]-fluoride
Author/Authors
Vasdev، نويسنده , , Neil and van Oosten، نويسنده , , Erik M. and Stephenson، نويسنده , , Karin A. and Zadikian، نويسنده , , Nonik and Yudin، نويسنده , , Andrei K. and Lough، نويسنده , , Alan J. and Houle، نويسنده , , Sylvain and Wilson، نويسنده , , Alan A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
544
To page
547
Abstract
A highly regioselective method was developed for ring-opening benzyloxycarbonyl (Cbz)-protected 2-methylaziridine with [18F]-labelled fluoride. Following catalytic hydrogenation, 1-[18F]fluoro-2-propanamine ([18F]1) and 2-[18F]fluoro-1-propanamine ([18F]2) were prepared as the major and minor products, respectively (85:15), and were characterized following acylation with benzyl chloride. This methodology is applicable towards the generation of new [18F]-labelled amines for incorporation into radiopharmaceuticals.
Keywords
aziridine , Fluorine-18 , ring-opening , Fluoroisopropylamine , PET , 1-Fluoro-2-propanamine , 2-Fluoro-1-propanamine
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862478
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