Title of article
Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine α ketoglutarate dioxygenase (TauD)
Author/Authors
McCusker، نويسنده , , Kevin P. and Klinman، نويسنده , , Judith P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
611
To page
613
Abstract
Taurine α-ketoglutarate dioxygenase (TauD) is an archetypal α-ketoglutarate-dependent non-heme iron oxygenase. Here, we report a practical five-step synthetic route to 1,1-dideutero-2-methylaminoethanesulfonic acid hydrochloride, a useful alternative substrate for the characterization of deuterium kinetic isotope effects on TauD.
Keywords
enzymes , isotope effects , stable isotopes , Mechanism
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862520
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