Title of article
Synthesis of furo[2,3-b]pyridin-4(7H)-ones and related quinolinone via Brّnsted acid-promoted cyclisation of alkynes
Author/Authors
David and Bossharth، نويسنده , , Emmanuel and Desbordes، نويسنده , , Philippe and Monteiro، نويسنده , , Nuno and Balme، نويسنده , , Geneviève، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
614
To page
616
Abstract
N-Alkyl-4-alkoxy-3-alkynylpyridin-2(1H)-ones readily undergo acid-promoted 5-endo-heteroannulation to furopyridinium intermediates that are dealkylated in situ to provide the corresponding furo[2,3-b]pyridin-4(7H)-ones. The same strategy applies to the formation of furo[2,3-b]quinolin-4(9H)-ones. In the case of Me3Si-substituted alkynes, hydration of the triple bond was observed.
Keywords
3-Alkynyl-2-pyridones , Electrophilic annulation , Brّnsted acids , Furopyridinium salts , 3-b]pyridin-4-ones
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862522
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