Title of article
Aza-annulation of β-enaminolactones: application to the synthesis of enantiopure difunctionalized bicyclic lactams
Author/Authors
Alladoum، نويسنده , , Jeanne and Toum، نويسنده , , Valérie and Hebbe، نويسنده , , Séverine and Kadouri-Puchot، نويسنده , , Catherine and Dechoux، نويسنده , , Luc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
617
To page
619
Abstract
Diastereoselective aza-annulation of seven-membered β-enaminolactones 2 gives access to bicyclic heterocyles 5. Fragmentation of molecule 5a with lithium methoxide affords cis or trans bicyclic lactams 8 with excellent stereoselectivities.
Keywords
aza-annulation , bicyclic lactams , ?-enaminoesters , intramolecular Michael addition
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862527
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