• Title of article

    Efficient conversion of thymine glycol into the formamide lesion in oligonucleotides

  • Author/Authors

    Toga، نويسنده , , Tatsuya and Yamamoto، نويسنده , , Junpei and Iwai، نويسنده , , Shigenori، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2009
  • Pages
    4
  • From page
    723
  • To page
    726
  • Abstract
    Oxidation of (5R,6S)-5,6-dihydro-5,6-dihydroxythymidine (thymidine glycol) with sodium periodate efficiently produced N-(2-deoxy-β-d-erythro-pentofuranosyl)formamide, a hydroxyl radical-induced decomposition product of pyrimidine bases in DNA, and this method was successfully applied to the conversion of thymine glycol in oligonucleotides into the formamide lesion.
  • Keywords
    Thymine glycol , Periodate oxidation , oligonucleotides , DNA damage
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2009
  • Journal title
    Tetrahedron Letters
  • Record number

    1862594

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1862594