Title of article
Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins
Author/Authors
Angelici، نويسنده , , Gaetano and Corrêa، نويسنده , , Rodrigo J. and Garden، نويسنده , , Simon J. and Tomasini، نويسنده , , Claudia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
814
To page
817
Abstract
The addition of small quantities of water to the proline or prolinamide-catalyzed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduce the observed enantioselectivity.
Keywords
DFT calculations , Isatin , organocatalysis , proline , water
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862648
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