Title of article
l-Proline-derived tertiary amino alcohol as a new chiral ligand for enantioselective alkynylation of aldehydes
Author/Authors
Xu، نويسنده , , Zhou and Wu، نويسنده , , Nan and Ding، نويسنده , , Zhenhua and Wang، نويسنده , , Ting and Mao، نويسنده , , Jincheng and Zhang، نويسنده , , Yawen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
926
To page
929
Abstract
The easily prepared chiral tertiary amino alcohol 1a was found to catalyze the reaction of alkynylzinc reagents with various aldehydes to generate chiral propargylic alcohols with moderate-to-good enantioselectivities. The mechanism of the reaction is also discussed in this Letter. A novel theoretical computation of those evaluated ligands was introduced which may supply valuable experience to help designing new chiral ligands.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862722
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