Title of article
A concise synthesis of honokiol
Author/Authors
Chen، نويسنده , , Chang-Ming and Liu، نويسنده , , Yeuk-Chuen Liu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
2
From page
1151
To page
1152
Abstract
A simple synthesis of the natural product honokiol 1 has been developed which proceeds in four steps and provides a 32% overall yield. Suzuki coupling of 4-allyl-2-bromoanisole 3 with 4-hydroxyphenyl boronic acid, followed by allylation, gave 5-allyl-4′-allyloxy-2-methoxy-biphenyl 5. This compound 5 underwent Lewis acid-catalyzed Claisen rearrangement and demethylation in a one-pot reaction which yielded honokiol.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862840
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