Title of article
Rationally designed 4-phenoxy substituted prolinamide phenols organocatalyst for the direct aldol reaction in water
Author/Authors
Zhang، نويسنده , , Shu-peng and Fu، نويسنده , , Xiang-kai and Fu، نويسنده , , Shao-dong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
1173
To page
1176
Abstract
A rationally designed 4-phenoxy substituted prolinamide phenols as an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1), and enantioselectivity (up to 97%) were obtained under optimal condition. The influence of substituent groups on the reactivity of catalysts was studied in detail.
Keywords
Asymmetric catalysis , organocatalysis , water , direct aldol reaction
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862852
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