Title of article
A general method for the synthesis of benzimidazole-4-sulfonamides
Author/Authors
Rosen، نويسنده , , Mark D. and Simon، نويسنده , , Zahna M. and Tarantino، نويسنده , , Kyle T. and Zhao، نويسنده , , Lucy X. and Rabinowitz، نويسنده , , Michael H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
1219
To page
1221
Abstract
A general method for the synthesis of benzimidazole-4-sulfonamides is described. This methodology employs commercially available benzothiadiazole-4-sulfonyl chloride as a benzimidazole equivalent. Reaction with a variety of amines followed by highly chemoselective reductive desulfurization gives intermediate 1,2-phenylenediamines, which may then react with aryl, heteroaryl, and alkyl aldehydes to provide substituted benzimidazole sulfonamides.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862873
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