Title of article
Highly cis- and trans-selective alkyl radical addition to α-methylene-γ-phenyl-γ-butyrolactams
Author/Authors
Yajima، نويسنده , , Tomoko and Hamano، نويسنده , , Masako and Nagano، نويسنده , , Hajime، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
2
From page
1301
To page
1302
Abstract
The 1,3-asymmetric induction in alkyl radical additions to α-methylene-γ-phenyl-γ-butyrolactams was investigated. The reactions of N-unsubstituted lactam using (Me3Si)3SiH under UV irradiation give cis-α,γ-disubstituted lactams, whereas reactions of N-pivaloyllactams using Et3B and Bu3SnH in the presence of Yb(OTf)3 give trans-α,γ-disubstituted lactams, both with high diastereoselectivities.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862907
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