A simple, novel and convenient method for the synthesis of 1-aminophosphinic acids: synthesis of a novel C2-symmetric phosphinic acid pseudodipeptide

A simple, efficient and novel method has been developed for the synthesis of 1-aminophosphinic acids from simple starting materials. Treatment of aromatic aldehydes with ammonia and hypophosphorus acid gives novel C2-symmetric 1-aminoarylmethylphosphinic acids. The synthesis of novel C2-symmetric phosphinic acid pseudodipeptides is also discussed.