Title of article
Total synthesis of 4-F3t-neuroprostane and its 4-epimer
Author/Authors
Auvinet، نويسنده , , Anne-Laure and Eignerovل، نويسنده , , Barbara and Guy، نويسنده , , Alexandre and Kotora، نويسنده , , Martin and Durand، نويسنده , , Thierry، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
1498
To page
1500
Abstract
The first synthesis of 4-F3t-Neuroprostane 1a and its 4-epimer is described. This molecule presents an important contribution to the study of neuronal oxidative stress in DHA-ω3 depleted brain. The key step involves the introduction of two unsaturated side chains into the chiral polyfunctional cyclopentane 4 via E selective HWE reaction and Z selective Wittig olefination for α and ω chains, respectively.
Keywords
oxidative stress , Wittig , total synthesis , Neuroprostane , HWE , DPA
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863013
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