Title of article
One-step diketopiperazine synthesis using phase transfer catalysis
Author/Authors
O’Reilly، نويسنده , , Elaine and Lestini، نويسنده , , Elena and Balducci، نويسنده , , Daniele and Paradisi، نويسنده , , Francesca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
1748
To page
1750
Abstract
A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%.
Keywords
Diketopiperazine , Phase transfer catalyst , TEBA , Chloroacetamide
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863154
Link To Document