Title of article
Facile conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-thiones to 2-(2-hydroxy-2-arylvinyl) dihydropyrimidines via Eschenmoser coupling
Author/Authors
Singh، نويسنده , , Sukhdeep and Schober، نويسنده , , Andreas and Gebinoga، نويسنده , , Michael and Alexander Groك، نويسنده , , G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
1838
To page
1843
Abstract
A one-pot, two-step synthesis protocol for the conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-thiones to 2-(2-hydroxy-2-arylvinyl) dihydropyrimidine (DHPM) derivatives via Eschenmoser sulfide contraction coupling is described. Solution phase as well as solid-supported protocol was carried out for the decoration of the Biginelli DHMP scaffold at the C-2 position. The scope of the optimized protocol is demonstrated for different DHMP precursors.
Keywords
Eschenmoser , Sulfide contraction , Eschenmoser coupling , Polymer supported , DHPM , Biginelli , Drug research , Privileged structure , Triphenylphosphine
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863228
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