Title of article
Facile reaction of thiols and amines with alkyl 4-hydroxy-2-alkynoates in water under neutral conditions and ultrasound irradiation
Author/Authors
Arcadi، نويسنده , , Antonio and Alfonsi، نويسنده , , Maria and Marinelli، نويسنده , , Fabio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
2060
To page
2064
Abstract
This Letter describes an alternative protocol for the Michael addition of thiols to 4-hydroxy-2-alkynoates. The reaction proceeds at room temperature in water under ultrasound irradiation. With amines instead of thiols a sequential conjugate addition/lactonization reaction leads to important 4-amino-furan-2-one derivatives.
Keywords
Amines , 4-Hydroxy-2-alkynoates , Ultrasound irradiation , Aqueous medium , Hetero-Michael reaction , thiols
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863402
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