Title of article
Influencing the regioselectivity of lipase-catalyzed hydrolysis with [bmim]PF6
Author/Authors
Gervaise، نويسنده , , Cédric and Daniellou، نويسنده , , Richard and Nugier-Chauvin، نويسنده , , Caroline and Ferrières، نويسنده , , Vincent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
2083
To page
2085
Abstract
An easy preparation of mono-deprotected thioglucopyranosides via a selective Candica cylindracea lipase-catalyzed hydrolysis of a commercially available peracetylated precursor is described. Especially, ethyl 2,3,4-tri-O-acetyl-1-thio-β-d-glucopyranoside and ethyl 2,3,6-tri-O-acetyl-1-thio-β-d-glucopyranoside were obtained in 100% and 54% isolated yields, respectively. The influence of the ratio of [bmim]PF6/buffer toward the regioselectivity of the deacetylation step and the acyl migration is discussed.
Keywords
Ionic liquid , carbohydrates , Lipase
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863422
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