Title of article
An efficient total synthesis of (+)-Cladospolide C
Author/Authors
Raji Reddy، نويسنده , , Ch. and Narsimha Rao، نويسنده , , N.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
2478
To page
2480
Abstract
The asymmetric synthesis of (+)-Cladospolide C has been achieved in 11 steps with 26% overall yield. Key steps in the sequence involve KAPA-promoted alkyne Zipper reaction, TPP-promoted enyne ester (ynoate) to diene ester (dienoate) isomerization, Sharpless asymmetric dihydroxylation and Yamaguchi macrolactonization.
Keywords
Ynoate isomerization , Yamaguchi macrolactonization , sharpless asymmetric dihydroxylation , Cladospolide , Alkyne zipper reaction
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863708
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