Title of article
Selective phenol alkylation for an improved synthesis of 2-arylbenzimidazole H4 receptor ligands
Author/Authors
Savall، نويسنده , , Brad M. and Fontimayor، نويسنده , , Jill R. and Edwards، نويسنده , , James P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
2490
To page
2492
Abstract
Alkylation of a phenol OH in the presence of a free benzimidazole NH was investigated and found to be highly dependent on the substitution of the benzimidazole and phenol rings. The modification of our original synthesis of 2-arylbenzimidazole H4 receptor ligands has resulted in improved yields and ease of isolation of final products.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863716
Link To Document