Title of article
New types of potential BNCT agents, o-carboranyl aminoalcohols
Author/Authors
Lee، نويسنده , , Chai-Ho and Jin، نويسنده , , Guo Fan and Joung، نويسنده , , Jung Gun and Lee، نويسنده , , Jong-Dae and Ban، نويسنده , , Hyun Seung and Nakamura، نويسنده , , Hiroyuki and Cho، نويسنده , , Jung-Keun and Kang، نويسنده , , Sang Ook، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
2960
To page
2963
Abstract
o-Carboranyl aminoalcohols were synthesized using a standard Mannich reaction, and were tested for their anticancer properties using an in vitro test for CT26 cancer cells. The polar periphery of the aminoalcohols benefited from the high boron uptake in CT26 cancer cells with low toxicity, indicating their potential as BNCT agents.
Keywords
Low cytotoxicity , Water solubility , boron neutron capture therapy , Boron accumulation , o-Carboranylphenol derivatives
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864092
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