Title of article
Trifluoromethylation of enamines under acidic conditions
Author/Authors
Gritsenko، نويسنده , , Roman T. and Levin، نويسنده , , Vitalij V. and Dilman، نويسنده , , Alexander D. and Belyakov، نويسنده , , Pavel A. and Struchkova، نويسنده , , Marina I. and Tartakovsky، نويسنده , , Vladimir A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
2994
To page
2997
Abstract
A method for the trifluoromethylation of enamines using Me3SiCF3 leading to α-CF3-substituted amines is described. The reaction is promoted by hydrofluoric acid generated from KHF2 and either trifluoroacetic or triflic acid, and involves protonation of the enamine followed by transfer of the CF3-carbanion from the silicon reagent to the cationic electrophile.
Keywords
trifluoromethylation , Iminium ions , enamines
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864116
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