Title of article
A simple O-sulfated thiohydroximate molecule to be the first micromolar range myrosinase inhibitor
Author/Authors
Deimante Cerniauskaite، نويسنده , , Deimante and Gallienne، نويسنده , , Estelle and Karciauskaite، نويسنده , , Henreta and Farinha، نويسنده , , Andrea S.F. and Rousseau، نويسنده , , Jolanta and Armand، نويسنده , , Sylvie and Tatibouët، نويسنده , , Arnaud and Sackus، نويسنده , , Algirdas and Rollin، نويسنده , , Patrick، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
3302
To page
3305
Abstract
New non-hydrolyzable analogues of glucosinolates have been prepared. Myrosinase inhibition was observed with modified aglycon moieties, even bulky phenothiazine analogue 6 gave reasonable inhibition. The simplest structure 8 derived from dimethylaminoethanethiol has shown to be the most potent inhibitor with an IC50 of 3.32 μM.
Keywords
glucosinolate , Myrosinase inhibition , sulfation , Thiohydroximate
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864310
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