Title of article
Total synthesis of (+)-spiculoic acid A
Author/Authors
Matsumura، نويسنده , , Daisuke and Toda، نويسنده , , Takumi and Hayamizu، نويسنده , , Takashi and Sawamura، نويسنده , , Kiyoto and Takao، نويسنده , , Ken-ichi and Tadano، نويسنده , , Kin-ichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
3356
To page
3358
Abstract
The total synthesis of natural (+)-spiculoic acid A, a new cytotoxic marine natural product of polyketide origin, has been accomplished for the first time. The key step of the total synthesis was a stereoselective and high-yielding intramolecular Diels–Alder reaction of a highly functionalized (E,E,E)-2,7,9-dodecanal derivative for the construction of the core tetrahydroindan-2-one skeleton.
Keywords
intramolecular Diels–Alder reaction , Suzuki–Miyaura coupling , (+)-Spiculoic acid A , total synthesis , Marine natural product , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864344
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