Title of article
Reductive amidation of nitroarenes: a practical approach for the amidation of natural products
Author/Authors
Wahba، نويسنده , , Amir E. and Peng، نويسنده , , Jiangnan and Hamann، نويسنده , , Mark T.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
3901
To page
3904
Abstract
A simple and practical approach for the one-pot conversion of nitroarenes into amide derivatives has been developed. Zinc and acetic acid are utilized as a reducing agent, and acyl chloride and triethylamine are used as the acylating agent in DMF with good yield (∼60%) of the amide. This method was applicable to manzamine A (1), where the yield of 6-cyclohexamidemanzamine A (7) was significantly improved (56%) by this approach relative to (17%) by beginning with the amine.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864764
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