Title of article
Cinchona alkaloid-derived quaternary ammonium salt combined with NaH: a facile catalyst system for the asymmetric trifluoromethylation of ketones
Author/Authors
Hu، نويسنده , , Xiaolei and Wang، نويسنده , , Jun and Li، نويسنده , , Wei and Lin، نويسنده , , Lili and Liu، نويسنده , , Xiaohua and Feng، نويسنده , , Xiaoming، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4378
To page
4380
Abstract
Enantioselective trifluoromethylation of aromatic ketones promoted by the cinchona alkaloid-derived ammonium bromide and sodium hydride was described. A series of trifluoromethyl-substituted aryl alcohols could be obtained in up to 82% ee with 98% yield under mild conditions. A possible catalytic cycle was also presented.
Keywords
ketones , Quaternary ammonium salt , Cinchona alkaloid , Sodium hydride , trifluoromethylation
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865121
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