Title of article
Cassaine diterpenoid dimers isolated from Erythrophleum succirubrum with TRAIL-resistance overcoming activity
Author/Authors
Miyagawa، نويسنده , , Takashi and Ohtsuki، نويسنده , , Takashi and Koyano، نويسنده , , Takashi and Kowithayakorn، نويسنده , , Thaworn and Ishibashi، نويسنده , , Masami، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
4658
To page
4662
Abstract
Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dimers, named erythrophlesins A–D (1–4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells.
Keywords
Diterpenoid dimer , Erythrophleum succirubrum , TRAIL-resistance overcoming activity , Cassaine
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865329
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