Title of article
Isolation, structure elucidation, and biological evaluation of the unusual heterodimer chrysoxanthone from the ascomycete IBWF11-95A
Author/Authors
Schüffler، نويسنده , , Anja and Liermann، نويسنده , , Johannes C. and Kolshorn، نويسنده , , Heinz and Opatz، نويسنده , , Till and Anke، نويسنده , , Heidrun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4813
To page
4815
Abstract
Chrysoxanthone, an unusual heterodimer of blennolide A and 2-hydroxychrysophanol linked through a diaryl ether bridge, was isolated from mycelia of the ascomycete IBWF11-95A grown in submerged culture. Its structure was elucidated by two-dimensional NMR spectroscopy. The metabolite shows antibacterial activity against different species with MIC values between 2.5 and 20 μg/mL while also inhibiting the growth of several fungi.
Keywords
natural products , Ergochrome , NMR spectroscopy , Structure elucidation , polyketides
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865433
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