An efficient green MCR protocol for the stereoselective synthesis of β-acetamido ketones catalyzed by Selectfluor™

An efficient, green, room temperature process for the stereoselective synthesis of β-amido ketones employing a one-pot multi-component reaction of aromatic aldehydes, α-substituted or α-unsubstituted ketones, an acid chloride, and a nitrile in presence of catalytic amount of Selectfluor™ is described. The process offers advantages such as high anti-selectivity, shorter reaction time, energy efficiency, and simple work-up.