Title of article
Diastereoselective Ti-mediated preparation of bicyclic aminocyclopropanes from N-alkenyl amides
Author/Authors
Madelaine، نويسنده , , Claire and Buzas، نويسنده , , Andrea K. and Kowalska-Six، نويسنده , , Justyna A. and Six، نويسنده , , Yvan and Crousse، نويسنده , , Benoît، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
5367
To page
5371
Abstract
Intramolecular Ti-mediated alkene–amide couplings of a range of N-alk-3-enyl amides fitted with a substituent at the homoallylic position are described. CF3-substituted compounds are suitable substrates and bicyclic aminocyclopropanes bearing a CF3 group can be prepared in this way. Good diastereoselectivities can be observed depending on the substitution pattern, and best results are obtained in diethyl ether rather than in THF.
Keywords
Kulinkovich-de Meijere reaction , Titanium , Cyclopropanes , Fluorine-substituted compounds
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865838
Link To Document