Title of article
Total synthesis of fomitellic acid B
Author/Authors
Yamaoka، نويسنده , , Makoto and Nakazaki، نويسنده , , Atsuo and Kobayashi، نويسنده , , Susumu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
6764
To page
6768
Abstract
Herein, we describe the first total synthesis of fomitellic acid B (2), a potent inhibitor of DNA polymerases α and β. There are two key features in this synthesis: (i) the AB ring system, with all requisite chiral centers, is stereoselectively constructed by means of titanium(III)-mediated radical cascade cyclization of epoxypolyene; and (ii) an enone moiety in the B-ring is generated by isomerization of an olefin followed by allylic oxidation.
Keywords
Triterpenoid , Fomitellic acid B , Titanium(III)-mediated radical cascade cyclization , total synthesis
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866838
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