Title of article
Combined solution-phase and solid-phase synthesis of 2-amino-7,8-dihydropteridin-6(5H)-ones
Author/Authors
Metzger، نويسنده , , Axel and Qin، نويسنده , , Lan-Ying and Cole، نويسنده , , Andrew G. and Saionz، نويسنده , , Kurt W. and Brescia، نويسنده , , Marc-Raleigh and Gstach، نويسنده , , Hubert and Wareing، نويسنده , , James R. and Zimmermann، نويسنده , , Juerg and Brill، نويسنده , , Wolfgang K-D. and Baldwin، نويسنده , , John J. and Dolle، نويسنده , , Roland E. and Henderson، نويسنده , , Ian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
7082
To page
7085
Abstract
An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones using a combination of solution-phase and solid-phase chemistry is described. Solution-phase chemistry was used to produce two pyrimidine regioisomers that were separated by flash column chromatography. Utilizing the desired regioisomer, solid-phase chemistry was used to effect the rapid construction of the substituted 2-amino-7,8-dihydropteridin-6(5H)-one system in high overall yield and purity.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1867076
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