Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles

A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different α-substituted fluoro(phenylsulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers.