Title of article
A simplified [11C]phosgene synthesis
Author/Authors
Bramoullé، نويسنده , , Yann and Roeda، نويسنده , , Dirk and Dollé، نويسنده , , Frédéric، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
313
To page
316
Abstract
A new flow-through system for the production of [11C]phosgene, a versatile labelling agent in radiochemistry for PET, is described. Cyclotron-produced [11C]CH4 is mixed with Cl2 and converted into [11C]CCl4 by passing the mixture through an empty quartz tube at 510 °C. The outflow is directed through a Sb-filled guard that takes out Cl2 and then, without intentional O2 addition, through a second empty quartz tube at 750 °C, giving rise to [11C]phosgene in 30–35% radiochemical yield.
Keywords
Radiolabelling , Carbon-11 , Phosgene
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870637
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