Title of article
A simple method for the oxidation of α-amino acid esters to α-oximino esters
Author/Authors
Wu، نويسنده , , Lisa Y. and Choi، نويسنده , , Joseph K. and Hatton، نويسنده , , Krit Y. and Berkman، نويسنده , , Clifford E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
402
To page
403
Abstract
Magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) was found to be an effective reagent for the oxidation of various α-amino acid esters to the corresponding α-oximino acid esters. This transformation could be completed under mild conditions within 2.5 h using 1.1 equiv of MMPP in THF. Clean oximino esters were obtained after quenching and extracting the reaction from sodium thiosulfate solution. The O-phosphorylated derivative of 2-oximinoglutarate exhibited slow binding inhibitory potency for the metallopeptidase prostate-specific membrane antigen (PSMA) with an IC50 value of 58 nM.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870702
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