Title of article
Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation
Author/Authors
Nair، نويسنده , , Sajiv K. and Matthews، نويسنده , , Jean J. and Cripps، نويسنده , , Stephan J. and Ma، نويسنده , , Chunrong and Dovalsantos، نويسنده , , Elena Z. and Grubbs، نويسنده , , Alan W. and Sach، نويسنده , , Neal W. and Hoeve، نويسنده , , Wolter ten and Koster، نويسنده , , Han and Flahive، نويسنده , , Erik J. and Tanis، نويسنده , , Steven P. and Renner، نويسنده , , Matt and Wiltenburg، نويسنده , , J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
1451
To page
1454
Abstract
A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastereoselective Sharpless asymmetric dihydroxylation to set the C-15 center.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871440
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