Title of article
From amines to diketopiperazines: a one-pot approach
Author/Authors
O’Reilly، نويسنده , , Elaine and Pes، نويسنده , , Lara and Paradisi، نويسنده , , Francesca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
1696
To page
1697
Abstract
An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium chloride (TEBA). The products are isolated in excellent yields of up to 90%.
Keywords
Benzyltriethylammonium chloride , Phase-transfer catalyst , one-pot synthesis , Diketopiperazine
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871581
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