Title of article
Enantioselective alkynylation of ketones with trimethoxysilylalkynes using lithium binaphtholate as a catalyst
Author/Authors
Tanaka، نويسنده , , Kana and Ueda، نويسنده , , Tomohiro and Ichibakase، نويسنده , , Tomonori and Nakajima، نويسنده , , Makoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
2168
To page
2169
Abstract
Chiral lithium 3,3′-diphenylbinaphtholate successfully catalyzed the alkynylation of ketone with trimethoxysilylalkyne, affording chiral tertiary propargylic alcohols in high chemical yields and high enantioselectivities. The present reaction could be extended to the alkynylation of acetylpyridine, which afforded a biologically active pyridyl propargylic alcohol in good enantioselectivity.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871983
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